@ EMBL-EBI

Publications

Highlighted

Web-based multi-omics integration using the Analyst software suite
Web-based multi-omics integration using the Analyst software suite
Jessica D. Ewald, Guangyan Zhou, Yao Lu, Jelena Kolic, Cara Ellis, James D. Johnson, Patrick E. Macdonald, Jianguo Xia
Nature Protocols  ·  14 Feb 2024  ·  doi:10.1038/s41596-023-00950-4
A protocol for multi-omics integration with user-friendly web-based tools that enable researchers to efficiently integrate different data types for scientific discovery.
Evaluating batch correction methods for image-based cell profiling
Evaluating batch correction methods for image-based cell profiling
John Arevalo, Ellen Su, Jessica D. Ewald, Robert van Dijk, Anne E. Carpenter, Shantanu Singh
Nature Communications  ·  02 Aug 2024  ·  doi:10.1038/s41467-024-50613-5

All

2025

Linking molecular pathways and islet cell dysfunction in human type 1 diabetes
Theodore dos Santos, Xiao Qing Dai, Robert C Jones, Aliya F Spigelman, Hannah M Mummey, …, Jianguo Xia, Joan Camunas-Soler, Kyle J Gaulton, Stephen Quake, Patrick E MacDonald
Cold Spring Harbor Laboratory  ·  21 Feb 2025  ·  doi:10.1101/2025.02.20.639325
Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes
Jessica D. Ewald, Katherine L Titterton, Alex Bäuerle, Alex Beatson, Daniil A Boiko, …, Srijit Seal, Erin Weisbart, Brandon White, Anne E. Carpenter, Shantanu Singh
Cold Spring Harbor Laboratory  ·  24 Jan 2025  ·  doi:10.1101/2025.01.22.634152

2024

Bioinformatic workflows for deriving transcriptomic points of departure: current status, data gaps, and research priorities
Jason O’Brien, Constance Mitchell, Scott Auerbach, Liam Doonan, Jessica Ewald, …, Matthew Wheeler, Deidre Dalmas Wilk, Andrew Williams, Carole Yauk, Eduardo Costa
Toxicological Sciences  ·  05 Nov 2024  ·  doi:10.1093/toxsci/kfae145
HumanIslets.com: Improving accessibility, integration, and usability of human research islet data
Jessica D. Ewald, Yao Lu, Cara E. Ellis, Jessica Worton, Jelena Kolic, …, James D. Johnson, Andrew R. Pepper, Francis C. Lynn, Jianguo Xia, Patrick E. MacDonald
Cell Metabolism  ·  01 Oct 2024  ·  doi:10.1016/j.cmet.2024.09.001
The DIKW of transcriptomics in ecotoxicology: extracting information, knowledge, and wisdom from big data
The DIKW of transcriptomics in ecotoxicology: extracting information, knowledge, and wisdom from big data
Jessica A Head, Jessica D Ewald, Niladri Basu
Environmental Toxicology and Chemistry  ·  12 Aug 2024  ·  doi:10.1002/etc.5954
Evaluating batch correction methods for image-based cell profiling
Evaluating batch correction methods for image-based cell profiling
John Arevalo, Ellen Su, Jessica D. Ewald, Robert van Dijk, Anne E. Carpenter, Shantanu Singh
Nature Communications  ·  02 Aug 2024  ·  doi:10.1038/s41467-024-50613-5
Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, …, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head
Environmental Toxicology and Chemistry  ·  29 Jul 2024  ·  doi:10.1002/etc.5955
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
Jelena Kolic, WenQing Grace Sun, Haoning Howard Cen, Jessica D. Ewald, Jason C. Rogalski, …, Francis C. Lynn, Anna L. Gloyn, Leonard J. Foster, Patrick E. MacDonald, James D. Johnson
Cell Metabolism  ·  01 Jul 2024  ·  doi:10.1016/j.cmet.2024.06.001
Maternal gastrointestinal nematode infection alters hippocampal neuroimmunity, promotes synaptic plasticity, and improves resistance to direct infection in offspring
Sophia C. Noel, Jeanne F. Madranges, Jean-David M. Gothié, Jessica Ewald, Austen J. Milnerwood, Timothy E. Kennedy, Marilyn E. Scott
Scientific Reports  ·  10 May 2024  ·  doi:10.1038/s41598-024-60865-2
Scaled mass index derived from aerial photogrammetry associated with predicted metabolic pathway disruptions in free-ranging St. Lawrence Estuary belugas
Meredith Sherrill, Alexandre Bernier-Graveline, Jessica Ewald, Zhiqiang Pang, Michel Moisan, Mathieu Marzelière, Maris Muzzy, Tracy A. Romano, Robert Michaud, Jonathan Verreault
Frontiers in Marine Science  ·  19 Apr 2024  ·  doi:10.3389/fmars.2024.1360374
Web-based multi-omics integration using the Analyst software suite
Web-based multi-omics integration using the Analyst software suite
Jessica D. Ewald, Guangyan Zhou, Yao Lu, Jelena Kolic, Cara Ellis, James D. Johnson, Patrick E. Macdonald, Jianguo Xia
Nature Protocols  ·  14 Feb 2024  ·  doi:10.1038/s41596-023-00950-4
A protocol for multi-omics integration with user-friendly web-based tools that enable researchers to efficiently integrate different data types for scientific discovery.
A data-centric perspective on exposomics data analysis
Le Chang, Jessica Ewald, Fiona Hui, Stéphane Bayen, Jianguo Xia
Exposome  ·  01 Jan 2024  ·  doi:10.1093/exposome/osae005

2023

Comparing transcriptomic responses to chemicals across six species using the EcoToxChip RNASeq database
Krittika Mittal, Jessica Ewald, Doug Crump, Jessica Head, Markus Hecker, Natacha Hogan, Jianguo Xia, Niladri Basu
Environmental Toxicology and Chemistry  ·  12 Dec 2023  ·  doi:10.1002/etc.5803
Hepatic Transcriptomic Responses to Ethinylestradiol in Embryonic Japanese Quail and Double-Crested Cormorant
Yeon-Seon Jeon, Jonathan Sangiovanni, Emily Boulanger, Doug Crump, Peng Liu, Jessica Ewald, Niladri Basu, Jianguo Xia, Markus Hecker, Jessica Head
Environmental Toxicology and Chemistry  ·  01 Dec 2023  ·  doi:10.1002/etc.5811
Using ExpressAnalyst for Comprehensive Gene Expression Analysis in Model and Non‐Model Organisms
Jessica Ewald, Guangyan Zhou, Yao Lu, Jianguo Xia
Current Protocols  ·  01 Nov 2023  ·  doi:10.1002/cpz1.922
ExpressAnalyst: A unified platform for RNA-sequencing analysis in non-model species
Peng Liu, Jessica Ewald, Zhiqiang Pang, Elena Legrand, Yeon Seon Jeon, …, Orcun Hacariz, Guangyan Zhou, Jessica A. Head, Niladri Basu, Jianguo Xia
Nature Communications  ·  24 May 2023  ·  doi:10.1038/s41467-023-38785-y
MicrobiomeAnalyst 2.0: comprehensive statistical, functional and integrative analysis of microbiome data
Yao Lu, Guangyan Zhou, Jessica Ewald, Zhiqiang Pang, Tanisha Shiri, Jianguo Xia
Nucleic Acids Research  ·  11 May 2023  ·  doi:10.1093/nar/gkad407

2022

Transcriptomic points of departure calculated from human intestinal cells exposed to dietary nanoparticles
Ke Xu, Krittika Mittal, Jessica Ewald, Samuel Rulli, Jennifer L. Jakubowski, Saji George, Niladri Basu
Food and Chemical Toxicology  ·  01 Dec 2022  ·  doi:10.1016/j.fct.2022.113501
A Systematic Review of Mercury Exposures from Skin-Lightening Products
Ashley Bastiansz, Jessica Ewald, Verónica Rodríguez Saldaña, Andrea Santa-Rios, Niladri Basu
Environmental Health Perspectives  ·  01 Nov 2022  ·  doi:10.1289/ehp10808
Characterizing Variability and Uncertainty Associated with Transcriptomic Dose–Response Modeling
Jessica D. Ewald, Niladri Basu, Doug Crump, Emily Boulanger, Jessica Head
Environmental Science & Technology  ·  21 Oct 2022  ·  doi:10.1021/acs.est.2c04665
Using MetaboAnalyst 5.0 for LC–HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data
Zhiqiang Pang, Guangyan Zhou, Jessica Ewald, Le Chang, Orcun Hacariz, Niladri Basu, Jianguo Xia
Nature Protocols  ·  17 Jun 2022  ·  doi:10.1038/s41596-022-00710-w
Transcriptomic Points of Departure Calculated from Rainbow Trout Gill, Liver, and Gut Cell Lines Exposed to Methylmercury and Fluoxetine
Krittika Mittal, Jessica Ewald, Niladri Basu
Environmental Toxicology and Chemistry  ·  27 May 2022  ·  doi:10.1002/etc.5395
Exposure to Contaminated River Water is Associated with Early Hatching and Dysregulation of Gene Expression in Early Life Stages of the Endangered Copper Redhorse (Moxostoma hubbsi)
H. Marchand, B. D. Barst, E. Boulanger, N. Vachon, M. Houde, …, P. Liu, J. D. Ewald, S. Bayen, L. Liu, J. A. Head
Environmental Toxicology and Chemistry  ·  27 May 2022  ·  doi:10.1002/etc.5391
OmicsNet 2.0: a web-based platform for multi-omics integration and network visual analytics
Guangyan Zhou, Zhiqiang Pang, Yao Lu, Jessica Ewald, Jianguo Xia
Nucleic Acids Research  ·  26 May 2022  ·  doi:10.1093/nar/gkac376
Comparative analysis of transcriptomic points-of-departure (tPODs) and apical responses in embryo-larval fathead minnows exposed to fluoxetine
Alper James G. Alcaraz, Shaina Baraniuk, Kamil Mikulášek, Bradley Park, Taylor Lane, …, Doug Crump, Niladri Basu, Natacha Hogan, Markus Brinkmann, Markus Hecker
Environmental Pollution  ·  01 Feb 2022  ·  doi:10.1016/j.envpol.2021.118667

2021

EcoToxXplorer: Leveraging Design Thinking to Develop a Standardized Web-Based Transcriptomics Analytics Platform for Diverse Users
Othman Soufan, Jessica Ewald, Guangyan Zhou, Orcun Hacariz, Emily Boulanger, …, Markus Hecker, Doug Crump, Jessica Head, Niladri Basu, Jianguo Xia
Environmental Toxicology and Chemistry  ·  11 Nov 2021  ·  doi:10.1002/etc.5251
Assessing the Toxicity of 17α-Ethinylestradiol in Rainbow Trout Using a 4-Day Transcriptomics Benchmark Dose (BMD) Embryo Assay
Alper James G. Alcaraz, Kamil Mikulášek, David Potěšil, Bradley Park, Kamran Shekh, …, David Schneider, Jianguo Xia, Doug Crump, Niladri Basu, Markus Hecker
Environmental Science & Technology  ·  22 Jul 2021  ·  doi:10.1021/acs.est.1c02401
Using Transcriptomics and Metabolomics to Understand Species Differences in Sensitivity to Chlorpyrifos in Japanese Quail and Double-Crested Cormorant Embryos
Jean-Pierre Desforges, Elena Legrand, Emily Boulager, Peng Liu, Jianguo Xia, …, Jessica Ewald, Niladri Basu, Markus Hecker, Jessica Head, Doug Crump
Environmental Toxicology and Chemistry  ·  22 Jul 2021  ·  doi:10.1002/etc.5174
OmicsAnalyst: a comprehensive web-based platform for visual analytics of multi-omics data
Guangyan Zhou, Jessica Ewald, Jianguo Xia
Nucleic Acids Research  ·  21 May 2021  ·  doi:10.1093/nar/gkab394
Ultrafast functional profiling of RNA-seq data for nonmodel organisms
Peng Liu, Jessica Ewald, Jose Hector Galvez, Jessica Head, Doug Crump, Guillaume Bourque, Niladri Basu, Jianguo Xia
Genome Research  ·  17 Mar 2021  ·  doi:10.1101/gr.269894.120

2020

FastBMD: an online tool for rapid benchmark dose–response analysis of transcriptomics data
Jessica Ewald, Othman Soufan, Jianguo Xia, Niladri Basu
Bioinformatics  ·  06 Aug 2020  ·  doi:10.1093/bioinformatics/btaa700
Selenium and stable mercury isotopes provide new insights into mercury toxicokinetics in pilot whales
Miling Li, C. Alicia Juang, Jessica D. Ewald, Runsheng Yin, Bjarni Mikkelsen, David P. Krabbenhoft, Prentiss H. Balcom, Clifton Dassuncao, Elsie M. Sunderland
Science of The Total Environment  ·  01 Mar 2020  ·  doi:10.1016/j.scitotenv.2019.136325
EcoToxModules: Custom Gene Sets to Organize and Analyze Toxicogenomics Data from Ecological Species
Jessica D. Ewald, Othman Soufan, Doug Crump, Markus Hecker, Jianguo Xia, Niladri Basu
Environmental Science & Technology  ·  28 Feb 2020  ·  doi:10.1021/acs.est.9b06607

2019

T1000: A reduced toxicogenomics gene set for improved decision making
Othman Soufan, Jessica Ewald, Charles Viau, Doug Crump, Markus Hecker, Niladri Basu, Jianguo Xia
PeerJ  ·  03 Jul 2019  ·  doi:10.7287/peerj.preprints.27839
NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis
Guangyan Zhou, Othman Soufan, Jessica Ewald, Robert E W Hancock, Niladri Basu, Jianguo Xia
Nucleic Acids Research  ·  01 Apr 2019  ·  doi:10.1093/nar/gkz240
Organ-specific differences in mercury speciation and accumulation across ringed seal (Phoca hispida) life stages
Jessica D. Ewald, Jane L. Kirk, Miling Li, Elsie M. Sunderland
Science of The Total Environment  ·  01 Feb 2019  ·  doi:10.1016/j.scitotenv.2018.09.299

2016

Environmental Origins of Methylmercury Accumulated in Subarctic Estuarine Fish Indicated by Mercury Stable Isotopes
Miling Li, Amina T. Schartup, Amelia P. Valberg, Jessica D. Ewald, David P. Krabbenhoft, Runsheng Yin, Prentiss H. Balcom, Elsie M. Sunderland
Environmental Science & Technology  ·  19 Oct 2016  ·  doi:10.1021/acs.est.6b03206